(S)-2((4-(N-Cbz)aminomethylbenzoyl)amino)-5-(N-Boc-2-picolylaminomethyl)valeric Acid → (S)-2-((4-aminomethylbenzoyl)amino)-5-(N-Boc-2-picolylaminomethyl)valeric Acid

HRID 11864Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 11864
C([NH:11][CH2:12][C:13]1[CH:44]=[CH:43][C:16]([C:17]([NH:19][C@@H:20]([CH2:24][CH2:25][CH2:26][CH2:27][N:28]([CH2:36][C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][N:38]=2)[C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])[C:21]([OH:23])=[O:22])=[O:18])=[CH:15][CH:14]=1)(OCC1C=CC=CC=1)=O>CO.[Pd]>[NH2:11][CH2:12][C:13]1[CH:14]=[CH:15][C:16]([C:17]([NH:19][C@@H:20]([CH2:24][CH2:25][CH2:26][CH2:27][N:28]([CH2:36][C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][N:38]=2)[C:29]([O:31][C:32]([CH3:35])([CH3:33])[CH3:34])=[O:30])[C:21]([OH:23])=[O:22])=[O:18])=[CH:43][CH:44]=1

Komponenten

4

Edukt 1

HCID 21043780(S)-2((4-(N-Cbz)aminomethylbenzoyl)amino)-5-(N-Boc-2-picolylaminomethyl)valeric Acid

Produkt 1

HCID 21043758(S)-2-((4-aminomethylbenzoyl)amino)-5-(N-Boc-2-picolylaminomethyl)valeric AcidAusbeute 64,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

The compound obtained in Example 41-4 (0.02 g) was dissolved in methanol (0.5 ml). After the addition of 10% Pd—C (0.02 g), the mixture was stirred for 2 hours under hydrogen atmosphere at room temperature. After the reaction, the catalyst was removed by filtration and solvent was removed by distillation. The residue was dried under vacuum to obtain the title compound (0.01 g) as colorless oil.

Aufarbeitung

  1. customAfter the reaction
  2. customthe catalyst was removed by filtration and solvent
  3. customwas removed by distillation
  4. customThe residue was dried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-ef91b828fa474015a55771cdc907c24a
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07098215B2

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