3-Methoxypropylamine → HCID 86617695, compound
Reaction equation
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][NH2:6].[S:7](N)([NH2:10])(=[O:9])=[O:8]>O1CCCC1>[CH3:1][O:2][CH2:3][CH2:4][CH2:5][NH:6][S:7](=[O:9])(=[O:8])[NH2:10]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 100 °C
Procedure
According to Reference Example 9-26, tetrahydrofuran (3 mL) and 3-methoxypropylamine (0.42 mL, 4.2 mmol) were added to sulfamide (400 mg, 4.2 mmol) and the mixture was stirred by use of a microwave chemical reactor at 300 W at 100° C. for 10 minutes. The solvent was evaporated off under reduced pressure, and purification by silica gel column chromatography (hexane/ethyl acetate=1/0 to 1/1) was performed to give N-(3-methoxypropyl)sulfuric diamide (Compound GG) (165 mg, yield: 24%).
Workup
- customThe solvent was evaporated off under reduced pressure, and purification by silica gel column chromatography (hexane/ethyl acetate=1/0 to 1/1)
Sources & evidence
- ORD record
- ord-0691fbc204e34ee9b3fdad92c1c6d4ab
- Source dataset
- uspto-grants-2014_03
- Patent number
- US08673908B2
Reaction notes
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