Ethoxyethylamine → HCID 86657940, compound

HRID 1186444Notes

Reaction equation

HRID 1186444 reaction equation
[CH2:1]([O:3][CH2:4][CH2:5][NH2:6])[CH3:2].[S:7](N)([NH2:10])(=[O:9])=[O:8]>O1CCCC1>[CH2:1]([O:3][CH2:4][CH2:5][NH:6][S:7](=[O:9])(=[O:8])[NH2:10])[CH3:2]

Participants

4

Reactant 2

HCID 66970EthoxyethylamineHCID 82267Sulfamide

Product 1

HCID 86657940HCID 86657940, compoundYield 42%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
100 °C

Procedure

According to Reference Example 9-26, tetrahydrofuran (3 mL) and 2-ethoxyethylamine (0.37 mL, 4.2 mmol) were added to sulfamide (400 mg, 4.2 mmol) and the mixture was stirred by use of a microwave chemical reactor at 300 W at 100° C. for 10 minutes. The solvent was evaporated off under reduced pressure, and purification by silica gel column chromatography (hexane/ethyl acetate=1/0 to 1/3) was performed to give N-(2-ethoxyethyl)sulfuric diamide (Compound GH) (296 mg, yield: 42%).

Workup

  1. customThe solvent was evaporated off under reduced pressure, and purification by silica gel column chromatography (hexane/ethyl acetate=1/0 to 1/3)

Sources & evidence

ORD record
ord-b6655efd4f154b889728f6d2cbbc9233
Source dataset
uspto-grants-2014_03
Patent number
US08673908B2

Reaction notes

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