反应详情

tert-Butyl 3,4,5,6-tetrahydro-1H-pyrrolo[3,4-C]pyrrole-2-carboxylate hydrochloride (30 g, 121.6 mmol) was suspended in 700 ml of methylene chloride, triethylamine (50.7 ml, 364.8 mmol) was added with ice bath cooling, and 2-(trifluoromethyl)benzoyl chloride (25.22 ml, 171.2 mmol) was slowly added dropwise. The brown suspension was stirred for 2 h, in the course of which it was allowed to come to RT. The reaction mixture was admixed with water, and the organic phase was removed, dried and concentrated by rotary evaporation. The crude product (56.8 g) was converted further without purification.

1. temperaturecooling
2. customto come to RT
3. customthe organic phase was removed
4. customdried
5. concentrationconcentrated by rotary evaporation
6. customThe crude product (56.8 g) was converted further without purification