反应详情

3,6-Dichloropyridazine (1.0 g, 6.712 mmol), 2-phenylethanol (820 mg, 6.712 mmol) and sodium hydride (60 percent suspension in oil, 268 mg, 6.712 mmol) were stirred in 25 ml of N-methylpyrrolidin-2-one at room temperature for 30 minutes. After concentrating, water and ethyl acetate were added, and the organic phase was removed, concentrated and purified by preparative HPLC (PR18, acetonitrile/water 0.1% TFA). Yield: 878 mg (56%), M+H+: 235.1.

1. concentrationAfter concentrating
2. additionwater and ethyl acetate were added
3. customthe organic phase was removed
4. concentrationconcentrated
5. custompurified by preparative HPLC (PR18, acetonitrile/water 0.1% TFA)