Diisopropylamine → 5-Bromo-4-fluoro-1,3-dihydro-2-benzofuran-1-one

Temperature

0 °C

A solution of n-BuLi (40 mL, 100 mmol) was added dropwise to a solution of diisopropylamine (10.6 g, 105 mmol) in 150 mL of THF at −70° C. The mixture was stirred at 0° C. for 15 minutes and then cooled to −70° C. again. A solution of 4-bromo-3-fluorobenzoic acid (10 g, 45.7 mmol, in 50 mL of THF) was added dropwise. The resulting mixture was stirred at −70° C. for 1 hour then CH2O gas (generated by heating 5.1 g of Para formaldehyde to 200° C.) was bubbled into the mixture. The resulting mixture was stirred at −70° C. for 1 hour then allowed to warm to room temperature and stirred for another 2 hours. HCl gas was bubbled into the suspension for 15 minutes to give a clear solution. The mixture was diluted with 1 L of EtOAc and washed subsequently with water, saturated Na2CO3 and brine, dried over anhydrous Na2SO4 and concentrated to give 5-bromo-4-fluoro-2-benzofuran-1(3H)-one as white solid.

1. temperaturecooled to −70° C. again
2. stirringThe resulting mixture was stirred at −70° C. for 1 hour
3. customCH2O gas (generated by heating 5.1 g of Para formaldehyde to 200° C.) was bubbled into the mixture
4. stirringThe resulting mixture was stirred at −70° C. for 1 hour
5. temperatureto warm to room temperature
6. stirringstirred for another 2 hours
7. customHCl gas was bubbled into the suspension for 15 minutes
8. customto give a clear solution
9. washwashed subsequently with water, saturated Na2CO3 and brine
10. dry with materialdried over anhydrous Na2SO4
11. concentrationconcentrated

ORD record

ord-2862bbf1f6044e4789bdb11b184b59aa

Source dataset

uspto-grants-2014_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08673920B2