反应详情

To a solution of methyl[3-bromo-2-(methyloxy)phenyl]acetate (8.20 g, 31.7 mmol) in 200 mL of dry THF under N2 at room temperature was added LiBH4 (32 mL, 63.32 mmol, 2M THF). After 1.5 hours, the reaction was warmed to reflux for 3 hours, and then cooled to room temperature. The solution was poured into EtOAc/1N HCl solution, and the layers were separated. The organic layer was washed with water, saturated Na2CO3 and brine, dried over anhydrous Na2SO4 and concentrated to give 2-[3-bromo-2-(methyloxy)phenyl]ethanol

1. temperaturethe reaction was warmed
2. temperatureto reflux for 3 hours
3. customthe layers were separated
4. washThe organic layer was washed with water, saturated Na2CO3 and brine
5. dry with materialdried over anhydrous Na2SO4
6. concentrationconcentrated