Tetrahydrofuran → (5-[(2,6-Difluoro-3,5-dimethoxy-phenylamino)-methyl]-2-methylsulfanyl-pyrimidin-4-yl)-ethyl-amine
Reaction equation
[Al+3:27].[F:1][c:2]1[c:3]([N:13]=[CH:14][c:15]2[c:16]([NH:23][CH2:24][CH3:25])[n:17][c:18]([S:21][CH3:22])[n:19][cH:20]2)[c:4]([F:12])[c:5]([O:10][CH3:11])[cH:6][c:7]1[O:8][CH3:9].[H-:26].[H-:29].[H-:30].[H-:31].[Li+:28].[O:32]1[CH2:33][CH2:34][CH2:35][CH2:36]1>>[F:1][c:2]1[c:3]([NH:13][CH2:14][c:15]2[c:16]([NH:23][CH2:24][CH3:25])[n:17][c:18]([S:21][CH3:22])[n:19][cH:20]2)[c:4]([F:12])[c:5]([O:10][CH3:11])[cH:6][c:7]1[O:8][CH3:9]Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-105548d08d0344d38c541934db26085f
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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