Ethyl Acetate → HCID 86623502, compound

The entire experiment was performed under an inert atmosphere by bubbling argon gas into the ice-salt cooled reaction mixture. To a cloudy solution of 5-benzyloxy-4-oxo-4H-pyran-2-carbaldehyde (5.00 g, 21.7 mmol) in dry tetrahydrofuran (185 mL) previously purged with argon for 35 min was added trimethyl(trifluoromethyl)silane (10.8 g, 76.0 mmol) dropwise, followed by caesium fluoride (0.34 g, 2.2 mmol). The color of the reaction mixture turned to yellow and almost clear within a min. TLC was used to monitor the reaction (eluant: 50:50, ethyl acetate:hexanes, v:v). The reaction was completed within 10 min. The reaction mixture was quenched with a 6.0N hydrochloric acid solution (20 mL) under cooling, followed by addition of a brine solution (50 mL). The mixture was stirred for 10 min, and then transferred to a separatory funnel. The organic THF fraction was collected, and then concentrated in vacuo to about 10 mL using the rotary evaporator. The residual solution was diluted with dichloromethane (80 mL). The mixture was transferred to a separatory funnel, and the separated dichloromethane layer was collected, dried over Na2SO4 and filtered. Upon concentration under reduced pressure, a first crop of the titled compound was obtained as a solid product (3.72 g, 57% yield, HPLC Method 1 (Example 24), RT=16.8 min, HPLC purity (peak percent area): 96% at λ=280 nm). 1H NMR (DMSO-d6+D2O) δ ppm: 8.20 (s, 1H), 7.36 (br m, 5H), 6.57 (s, 1H), 5.11 (q, J=7 Hz, 1H), 4.92 (s, 2H).

1. customby bubbling argon gas into the ice-salt
2. temperaturecooled
3. customreaction mixture
4. customThe reaction mixture was quenched with a 6.0N hydrochloric acid solution (20 mL)
5. temperatureunder cooling
6. additionfollowed by addition of a brine solution (50 mL)
7. customtransferred to a separatory funnel
8. customThe organic THF fraction was collected
9. concentrationconcentrated in vacuo to about 10 mL
10. customthe rotary evaporator
11. additionThe residual solution was diluted with dichloromethane (80 mL)
12. customThe mixture was transferred to a separatory funnel
13. customthe separated dichloromethane layer was collected
14. dry with materialdried over Na2SO4
15. filtrationfiltered
16. concentrationUpon concentration under reduced pressure

ORD record

ord-6738953f7f514eab98d419c87310923b

Source dataset

uspto-grants-2014_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08673943B2