反应详情

334 mg of 1-benzhydryl-3-cyclopropylazetidin-3-ol was dissolved in dimethylformamide, and 72 mg of 60% sodium hydride was added thereto, and the mixture was stirred at room temperature for 30 minutes. 112 μl of methyl iodide was added thereto, and the mixture was further stirred at room temperature for 2 hours. To the reaction solution was added water and the mixture was subjected to extraction with diethyl ether, and dried over magnesium sulfate. The solvent was distilled off under reduced pressure, and then the obtained residue was purified by silica gel column chromatography to obtain 280 mg of the objective compound.

1. stirringthe mixture was further stirred at room temperature for 2 hours
2. extractionthe mixture was subjected to extraction with diethyl ether
3. dry with materialdried over magnesium sulfate
4. distillationThe solvent was distilled off under reduced pressure
5. customthe obtained residue was purified by silica gel column chromatography