Hydrochloric Acid → HCID 86643473, compound

HRID 1188113Notes

Reaction equation

HRID 1188113 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8]1[S:9][C:10]([CH2:13][NH:14][C:15]2[S:16][CH:17]=[CH:18][N:19]=2)=[CH:11][N:12]=1.CCOCC.[ClH:25]>>[ClH:25].[ClH:25].[ClH:25].[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8]1[S:9][C:10]([CH2:13][NH:14][C:15]2[S:16][CH:17]=[CH:18][N:19]=2)=[CH:11][N:12]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 25001111HCID 25001111, compound

Product 1

HCID 86643473HCID 86643473, compound

Procedure

N-(Pyridin-2-yl)-5-((thiazol-2-ylamino)methyl)thiazol-2-amine (15 mg, 0.05 mmol) was dissolved in methanolic HCl (3 N, 1 mL) and Et2O was added. The precipitated solid was filtered by decantation and dried in vacuum, yielding N-(pyridin-2-yl)-5-((thiazol-2-ylamino)methyl)thiazol-2-amine trihydrochloride (14 mg, 2%, 95.5% pure by HPLC).

Workup

  1. filtrationThe precipitated solid was filtered by decantation
  2. customdried in vacuum

Sources & evidence

ORD record
ord-87432a78de5c47ff8b6bebd67e8f68cd
Source dataset
uspto-grants-2014_03
Patent number
US08673940B2

Reaction notes

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