Hydrochloric Acid → HCID 86643474, compound

HRID 1188129Notes

Reaction equation

HRID 1188129 reaction equation
[CH3:1][NH:2][C:3]1[S:4][C:5]([CH2:8][NH:9][C:10]2[S:11][CH:12]=[CH:13][N:14]=2)=[CH:6][N:7]=1.CCOCC.[ClH:20]>>[ClH:20].[ClH:20].[CH3:1][NH:2][C:3]1[S:4][C:5]([CH2:8][NH:9][C:10]2[S:11][CH:12]=[CH:13][N:14]=2)=[CH:6][N:7]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 25001115HCID 25001115, compound

Product 1

HCID 86643474HCID 86643474, compoundYield 79%

Procedure

N-Methyl-5-((thiazol-2-ylamino)methyl)thiazol-2-amine (28 mg, 0.12 mmol) was dissolved in methanolic HCl (3 N, 1 mL) and Et2O was added. The precipitated solid was filtered by decantation and dried in vacuo, yielding N-methyl-5-((thiazol-2-ylamino)methyl)thiazol-2-amine dihydrochloride as a white solid (29 mg, 79%). Mp. 128-130° C.

Workup

  1. filtrationThe precipitated solid was filtered by decantation
  2. customdried in vacuo

Sources & evidence

ORD record
ord-58f89f5b3761473b89d21608d1fc2d9a
Source dataset
uspto-grants-2014_03
Patent number
US08673940B2

Reaction notes

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