HCID 59408770, compound → HCID 59408767, compound

HRID 1188133Notes

Reaction equation

HRID 1188133 reaction equation
Br[C:2]1[N:7]=[C:6]([NH:8][C:9]([C:11]2[CH:15]=[C:14]([C:16]3[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=3)[N:13]([CH:23]3[CH2:28][CH2:27][CH2:26][CH2:25][O:24]3)[N:12]=2)=[O:10])[CH:5]=[CH:4][CH:3]=1>C(N)CC>[CH2:14]([NH:13][C:2]1[N:7]=[C:6]([NH:8][C:9]([C:11]2[CH:15]=[C:14]([C:16]3[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=3)[N:13]([CH:23]3[CH2:28][CH2:27][CH2:26][CH2:25][O:24]3)[N:12]=2)=[O:10])[CH:5]=[CH:4][CH:3]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 1

HCID 59408770HCID 59408770, compound

Product 1

HCID 59408767HCID 59408767, compoundYield 124.4%

Reagents, catalysts & solvents 1

HCID 7852PropylamineSolvent

Procedure

A solution of 6-bromo-N-(5-bromopyridin-2-yl)nicotinamide 3 (1.1 g, 3.0 mmol) in n-propylamine (neat, 5 ml) was heated at 80° C. for 2 days. Then the solvent was evaporated to give 6-(propylamino)-N-(5-(propylamino)pyridin-2-yl)nicotinamide 4 as a white solid (880 mg, 91%). Mp. 134-135° C.

Workup

  1. customThen the solvent was evaporated

Sources & evidence

ORD record
ord-ea7902b3b11546d7b262de4990618004
Source dataset
uspto-grants-2014_03
Patent number
US08673940B2

Reaction notes

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