反应详情

温度

0 °C

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of [2-(5-acetyl-thiophen-2-ylmethyl)-thiazol-4-yl]-carbamic acid tert-butyl ester (75 mg, 0.22 mmol) in dry CH2Cl2 (2.2 mL) was treated at 0° C. with HCl (0.55 mL of a 4M solution in dioxane, 2.22 mmol). After stirring at 0° C. for 1 h, the reaction mixture was stirred at rt for 16 h. The solvents were removed under reduced pressure to give the title compound as a light brown solid. LC-MS-conditions 02: tR=0.71 min, [M+AcCN+H]+=280.14.

1. stirringthe reaction mixture was stirred at rt for 16 h
2. customThe solvents were removed under reduced pressure