反应详情

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of [5-(3-fluoro-phenyl)-thiazole-4-carbonyl]-[2-(5-oxo-hexyl)-oxazol-4-yl]-carbamic acid tert-butyl ester (30 mg, 0.06 mmol) in dry CH2Cl2 (1.0 mL) was treated at 0° C. with trifluoroacetic acid (0.05 mL, 0.64 mmol). After stirring at rt for 3 h, the reaction mixture was quenched with sat. aq. NaHCO3, extracted with CH2Cl2 (3×10 mL) and the combined org. extracts were dried over Na2SO4, filtered, and the solvents were removed under reduced pressure. Purification of the residue by HPLC gave the title compound as a colorless oil. LC-MS-conditions 01: tR=0.99 min, [M+H]+=388.04.

1. customthe reaction mixture was quenched with sat. aq. NaHCO3
2. extractionextracted with CH2Cl2 (3×10 mL)
3. dry with materialextracts were dried over Na2SO4
4. filtrationfiltered
5. customthe solvents were removed under reduced pressure
6. customPurification of the residue by HPLC