Diethyl Oxalate → HCID 67133792, compound

HRID 1189450Notes

Reaction equation

HRID 1189450 reaction equation
[NH2:1][C:2]1[C:11]([NH2:12])=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([CH3:13])[CH:3]=1.[C:14](OCC)(=[O:20])[C:15](OCC)=[O:16]>>[CH3:13][C:4]1[CH:3]=[C:2]2[C:11]([NH:12][C:14](=[O:20])[C:15](=[O:16])[NH:1]2)=[CH:10][C:5]=1[C:6]([O:8][CH3:9])=[O:7]

Participants

3

Reactant 2

HCID 7268Diethyl OxalateHCID 585752204,5-Diamino-2-methyl-benzoic acid methyl ester

Product 1

HCID 67133792HCID 67133792, compound

Conditions

Temperature
145 °C

Procedure

A mixture of 3.98 g of methyl 4,5-diamino-2-methylbenzoate and 40 mL of diethyl oxalate was stirred at 145° C. for 3 hours. After cooling to room temperature, the solid was collected by filtration, washed with diethyl ether, and dried under reduced pressure to obtain 4.75 g of methyl 7-methyl-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carboxylate.

Workup

  1. temperatureAfter cooling to room temperature
  2. filtrationthe solid was collected by filtration
  3. washwashed with diethyl ether
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-3df71f11c02f4646a2f9f52a8d942c27
Source dataset
uspto-grants-2014_03
Patent number
US08674096B2

Reaction notes

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