Ethyl-2-[4-trifluoromethyl-piperidinyl]-4-methylamino-5-nitro-benzoate → HCID 67956899, compound

HRID 1189652Notes

Reaction equation

HRID 1189652 reaction equation
[CH2:1]([O:3][C:4](=[O:26])[C:5]1[CH:10]=[C:9]([N+:11]([O-])=O)[C:8]([NH:14][CH3:15])=[CH:7][C:6]=1[N:16]1[CH2:21][CH2:20][CH:19]([C:22]([F:25])([F:24])[F:23])[CH2:18][CH2:17]1)[CH3:2]>[Ni].C1COCC1>[CH2:1]([O:3][C:4](=[O:26])[C:5]1[CH:10]=[C:9]([NH2:11])[C:8]([NH:14][CH3:15])=[CH:7][C:6]=1[N:16]1[CH2:17][CH2:18][CH:19]([C:22]([F:23])([F:24])[F:25])[CH2:20][CH2:21]1)[CH3:2]

Participants

4

Reactant 1

HCID 67957612Ethyl-2-[4-trifluoromethyl-piperidinyl]-4-methylamino-5-nitro-benzoate

Product 1

HCID 67956899HCID 67956899, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of ethyl-2-[4-trifluoromethyl-piperidinyl]-4-methylamino-5-nitro-benzoate (380 mg, 1.01 mmol), Ra—Ni (500 mg) and THF (20 mL) is stirred overnight under 10 bar H2-atmosphere. The mixture is filtered, and the filtrate is concentrated.

Workup

  1. filtrationThe mixture is filtered
  2. concentrationthe filtrate is concentrated

Sources & evidence

ORD record
ord-4d0e7f2c602243429fbfb5fb8f03c6b1
Source dataset
uspto-grants-2014_03
Patent number
US08674113B2

Reaction notes

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