Hydrochloric Acid → HCID 86666471, compound

HRID 1189659Notes

Reaction equation

HRID 1189659 reaction equation
[F:1][C:2]([F:29])([F:28])[O:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:27])[C:12]2[CH:17]=[C:16]([N+:18]([O-:20])=[O:19])[C:15]([NH:21][CH2:22][CH:23]([F:25])[F:24])=[CH:14][C:13]=2Cl)=[CH:6][CH:5]=1.[F:30][C@@H:31]1[CH2:35][CH2:34][NH:33][CH2:32]1.Cl.CCN(C(C)C)C(C)C>CC#N>[F:1][C:2]([F:29])([F:28])[O:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:27])[C:12]2[CH:17]=[C:16]([N+:18]([O-:20])=[O:19])[C:15]([NH:21][CH2:22][CH:23]([F:25])[F:24])=[CH:14][C:13]=2[N:33]2[CH2:34][CH2:35][C@@H:31]([F:30])[CH2:32]2)=[CH:6][CH:5]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 81531DiisopropylethylamineHCID 27591633-FluoropyrrolidineHCID 86666470HCID 86666470, compound

Product 1

HCID 86666471HCID 86666471, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The sub-title compound is prepared in analogy to 6a from N-(4-trifluoromethoxy-phenyl)-2-chloro-4-(2,2-difluoro-ethylamino)-5-nitro-benzoic acid amide (177 mg, 0.40 mmol), (R)-3-fluoro-pyrrolidine×HCl (56 mg, 0.44 mmol), DIPEA (0.55 mL, 3.2 mmol) and MeCN (5 mL).

Sources & evidence

ORD record
ord-cbcd1146e9844ff0ba4d03e0a66cc515
Source dataset
uspto-grants-2014_03
Patent number
US08674113B2

Reaction notes

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