Diisopropylcarbodiimide → HCID 178482831, compound

HRID 1189671Notes

Reaction equation

HRID 1189671 reaction equation
[F:1][C:2]([F:32])([F:31])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:30])[C:11]2[CH:16]=[C:15]([NH2:17])[C:14]([NH:18][CH3:19])=[CH:13][C:12]=2[N:20]([CH3:29])[CH2:21][C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=2)[CH2:5][CH2:4]1.[Cl:33][C:34]1[C:47]([N:48]=[C:49]=S)=[C:46]([Cl:51])[CH:45]=[CH:44][C:35]=1[CH2:36][NH:37][C:38](=[O:43])[C:39]([CH3:42])([CH3:41])[CH3:40].CC(C)N=C=NC(C)C>CN(C=O)C>[F:31][C:2]([F:1])([F:32])[C@H:3]1[CH2:4][CH2:5][C@H:6]([NH:9][C:10]([C:11]2[C:12]([N:20]([CH3:29])[CH2:21][C:22]3[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=3)=[CH:13][C:14]3[N:18]([CH3:19])[C:49]([NH:48][C:47]4[C:46]([Cl:51])=[CH:45][CH:44]=[C:35]([CH2:36][NH:37][C:38](=[O:43])[C:39]([CH3:42])([CH3:41])[CH3:40])[C:34]=4[Cl:33])=[N:17][C:15]=3[CH:16]=2)=[O:30])[CH2:7][CH2:8]1

Participants

5

Reactant 3

HCID 12734DiisopropylcarbodiimideHCID 56840192N-[(2,4-dichloro-3-isothiocyanatophenyl)methyl]-2,2-dimethylpropanamideHCID 178482254HCID 178482254, compound

Product 1

HCID 178482831HCID 178482831, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound is prepared in analogy to 1e from N-(trans-4-trifluoromethyl-cyclohexyl)-2-[N-methyl-N-(4-fluorobenzyl)amino]-4-methylamino-5-amino-benzoic acid amide (68 mg, 0.15 mmol), and N-(2,4-dichloro-3-isothiocyanato-benzyl)-2,2-dimethyl-propionamide (48 mg, 0.15 mmol), DIC (23 μL) and DMF (2.0 mL).

Sources & evidence

ORD record
ord-cfa653093fc54e119cab3685ace5fb09
Source dataset
uspto-grants-2014_03
Patent number
US08674113B2

Reaction notes

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