Hydrochloric Acid → HCID 178482286, compound

HRID 1189682Notes

Reaction equation

HRID 1189682 reaction equation
[F:1][C:2]([F:26])([F:25])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:24])[C:11]2[CH:16]=[C:15]([N+:17]([O-:19])=[O:18])[C:14]([NH:20][CH3:21])=[C:13]([F:22])[C:12]=2F)[CH2:5][CH2:4]1.[F:27][C@@H:28]1[CH2:32][CH2:31][NH:30][CH2:29]1.Cl.CCN(C(C)C)C(C)C>CC#N>[F:1][C:2]([F:25])([F:26])[C@H:3]1[CH2:4][CH2:5][C@H:6]([NH:9][C:10](=[O:24])[C:11]2[CH:16]=[C:15]([N+:17]([O-:19])=[O:18])[C:14]([NH:20][CH3:21])=[C:13]([F:22])[C:12]=2[N:30]2[CH2:31][CH2:32][C@@H:28]([F:27])[CH2:29]2)[CH2:7][CH2:8]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 81531DiisopropylethylamineHCID 27591633-FluoropyrrolidineHCID 178482284HCID 178482284, compound

Product 1

HCID 178482286HCID 178482286, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The sub-title compound is prepared in analogy to procedure 6a from N-(trans-4-trifluoromethyl-cyclohexyl)-2,3-difluoro-4-methylamino-5-nitro-benzoic acid amide (200 mg, 0.52 mmol), (R)-3-fluoropyrrolidine×HCl (72 mg, 0.57 mmol), DIPEA (0.76 mL, 4.4 mmol) and MeCN (5 mL). Yield: 230 mg. HPLC Rt=1.52 min (method A). MS m/z: 451 [M+H]+.

Sources & evidence

ORD record
ord-d80db3ed2589441499bd34d16e86e663
Source dataset
uspto-grants-2014_03
Patent number
US08674113B2

Reaction notes

Loading…