Allylamine → N-Allyl-2,2,2-trifluoroacetamide

HRID 1190791Notes

Reaction equation

HRID 1190791 reaction equation
C(O[C:4](=[O:9])[C:5]([F:8])([F:7])[F:6])C.[CH2:10]([NH2:13])[CH:11]=[CH2:12].C(N(CC)C(C)C)(C)C>CO>[F:8][C:5]([F:6])([F:7])[C:4]([NH:13][CH2:10][CH:11]=[CH2:12])=[O:9]

Participants

5

Reactant 3

HCID 7853AllylamineHCID 9794Ethyl trifluoroacetateHCID 81531Diisopropylethylamine

Product 1

HCID 558569N-Allyl-2,2,2-trifluoroacetamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Ethyltrifluoroacetate (14.2 grams, 100 mmol) was added to a solution of allylamine (4.05 grams, 6 ml, 80 mmol) and N,N-diisopropylethyl amine (10.32 grams 7.3 ml, 80 mmol) in methanol (30 ml). The reaction mixture was stirred at room temperature for 15 hours. The solvent was thereafter removed under reduced pressure and the product (see, Compound 1 in Scheme 1 below) was extracted with ethyl acetate.

Workup

  1. customThe solvent was thereafter removed under reduced pressure
  2. extractionthe product (see, Compound 1 in Scheme 1 below) was extracted with ethyl acetate

Sources & evidence

ORD record
ord-f2c92f64ca7245ada1ae048db62715da
Source dataset
uspto-grants-2014_03
Patent number
US08680062B2

Reaction notes

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