Trifluoroacetic acid → HCID 70975458, compound

HRID 1190800Notes

Reaction equation

[F:1][C:2]1[CH:29]=[CH:28][C:27]([F:30])=[CH:26][C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[N:9][CH:10]=[CH:11][C:12]=2[N:14]2[CH2:19][CH2:18][CH2:17][C@@H:16]([NH:20]C(=O)O)[CH2:15]2)[N:7]([CH3:24])[C:6]1=[O:25].[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34]>>[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34].[F:1][C:2]1[CH:29]=[CH:28][C:27]([F:30])=[CH:26][C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[N:9][CH:10]=[CH:11][C:12]=2[N:14]2[CH2:19][CH2:18][CH2:17][C@@H:16]([NH2:20])[CH2:15]2)[N:7]([CH3:24])[C:6]1=[O:25]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 86673546HCID 86673546, compound

Product 1

HCID 70975458HCID 70975458, compoundYield 77.4%

Procedure

The specific operation referred to the step (6) described in Example 1. 264 mg (R)-1-[1-(2,5-difluorobenzyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl]piperidin-3-yl carbamic acid ter.-butyl ester (0.558 mmol) and 3.83 mL trifluoroacetic acid were charged to afford 161 mg titled product with a yield of 77.4%.

Sources & evidence

ORD record: ord-9c95aca83eff4ff19b2d20314decc1cb
Source dataset: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08680089B2

Reaction notes

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