Trifluoroacetic acid → HCID 70975387, compound

HRID 1190801Notes

Reaction equation

[Cl:1][C:2]1[CH:29]=[CH:28][CH:27]=[CH:26][C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[N:9][CH:10]=[CH:11][C:12]=2[N:14]2[CH2:19][CH2:18][CH2:17][C@@H:16]([NH:20]C(=O)O)[CH2:15]2)[N:7]([CH3:24])[C:6]1=[O:25].[F:30][C:31]([F:36])([F:35])[C:32]([OH:34])=[O:33]>>[F:30][C:31]([F:36])([F:35])[C:32]([OH:34])=[O:33].[Cl:1][C:2]1[CH:29]=[CH:28][CH:27]=[CH:26][C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[N:9][CH:10]=[CH:11][C:12]=2[N:14]2[CH2:19][CH2:18][CH2:17][C@@H:16]([NH2:20])[CH2:15]2)[N:7]([CH3:24])[C:6]1=[O:25]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 86673547HCID 86673547, compound

Product 1

HCID 70975387HCID 70975387, compoundYield 60.2%

Procedure

The specific operation referred to the step (6) described in Example 1 for details. 161 mg (R)-1-[1-(2-chlorobenzyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl]piperidin-3-yl carbamic acid ter.-butyl ester (0.342 mmol) and 2.4 mL trifluoroacetic acid were charged to afford 100 mg titled product with a yield of 60.2%.

Sources & evidence

ORD record: ord-c51665bcc4fb499ab8cf497884613564
Source dataset: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08680089B2

Reaction notes

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