反应详情

2-Fluoro-5-nitrobenzyl alcohol (1 g, 5.84 mmol) and N-methylpiperazine (1.29 mL, 2 eq) were heated at 130° C. for 1 h. The reaction mixture was then diluted with 25 mL of THF and washed with a saturated aqueous solution of Na2CO3 and then with brine. The organic layer was dried over Na2SO4, filtered and evaporated. The residue was thoroughly washed with pentane and filtered off to yield expected compound as an orange powder (1.38 g, 94% yield). m/z (ESI) 252.1 [M+H]+.

1. washwashed with a saturated aqueous solution of Na2CO3
2. dry with materialThe organic layer was dried over Na2SO4
3. filtrationfiltered
4. customevaporated
5. washThe residue was thoroughly washed with pentane
6. filtrationfiltered off