Hydrochloric Acid → HCID 67463701, compound

HRID 1190951Notes

Reaction equation

HRID 1190951 reaction equation
[ClH:1].C(OC([NH:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]2[N:18]=[C:19]([NH:22][CH3:23])[O:20][CH:21]=2)=[CH:13][CH:12]=1)=O)(C)(C)C>O1CCOCC1.C(Cl)Cl>[ClH:1].[CH3:23][NH:22][C:19]1[O:20][CH:21]=[C:17]([C:14]2[CH:15]=[CH:16][C:11]([CH2:10][NH2:9])=[CH:12][CH:13]=2)[N:18]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 59828841HCID 59828841, compound

Product 1

HCID 67463701HCID 67463701, compoundYield 95%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

Add 4N hydrogen chloride in dioxane (10.5 mL) to a solution of N-(tert-butoxycarbonyl)-4-(2-methylamino-oxazol-4-yl)-benzylamine (624 mg, 1.6 mmol) in DCM (250 mL). Stir the solution at room temperature for 16 h in a sealed flask. Concentrate the mixture in vacuo to a solid. Slurry the solid in excess of diethyl ether and filter. Collect the white solid to obtain the title compound (1.48 g, 95%). MS (ES+) m/z: 204.1 (M+H)+.

Workup

  1. concentrationConcentrate the mixture in vacuo to a solid
  2. filtrationfilter
  3. customCollect the white solid

Sources & evidence

ORD record
ord-133f913feb1d4455a1b7abf371aaf0ac
Source dataset
uspto-grants-2014_03
Patent number
US08680091B2

Reaction notes

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