Hydrazine hydrate (1:1) → HCID 86634373, compound

HRID 1191274Notes

Reaction equation

HRID 1191274 reaction equation
[N:1]([CH2:4][C@@H:5]1[C@@H:9]([N:10]2C(=O)C3C(=CC=CC=3)C2=O)[CH2:8][CH2:7][N:6]1[C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])=[N+:2]=[N-:3].O.NN>CO>[NH2:10][C@H:9]1[CH2:8][CH2:7][N:6]([C:21]([O:23][C:24]([CH3:26])([CH3:27])[CH3:25])=[O:22])[C@@H:5]1[CH2:4][N:1]=[N+:2]=[N-:3]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 86634372HCID 86634372, compound

Product 1

HCID 86634373HCID 86634373, compoundYield 76.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of the compound 6 (493 mg) in methanol (13 mL), hydrazine monohydrate (339 mg) was added. The reaction mixture was stirred at room temperature for overnight. The reaction mixture was concentrated and then added dichloromethane. The appeared solid was collected by filtration and then the residue was concentrated and obtained the title compound (245 mg) having the following physical properties.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. filtrationThe appeared solid was collected by filtration
  3. concentrationthe residue was concentrated

Sources & evidence

ORD record
ord-00de2ad39c774f97be6ca7f893a62d16
Source dataset
uspto-grants-2014_03
Patent number
US08680092B2

Reaction notes

Loading…