HCID 68916161, compound → HCID 68918306, compound

HRID 1191296Notes

Reaction equation

HRID 1191296 reaction equation
[N:1]1([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([NH:14][C@H:15]3[CH2:19][CH2:18][N:17]([CH:20]4[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]4)[C@@H:16]3[CH2:26][NH:27][S:28]([CH2:31][CH2:32][N:33]3C(=O)C4C(=CC=CC=4)C3=O)(=[O:30])=[O:29])[N:9]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>CO.O.NN>[NH2:33][CH2:32][CH2:31][S:28]([NH:27][CH2:26][C@@H:16]1[C@@H:15]([NH:14][C:10]2[N:9]=[C:8]([N:1]3[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]3)[CH:13]=[CH:12][N:11]=2)[CH2:19][CH2:18][N:17]1[CH:20]1[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1)(=[O:29])=[O:30]

Participants

4

Reactant 1

HCID 68916161HCID 68916161, compound

Product 1

HCID 68918306HCID 68918306, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 24654Hydrazine hydrate (1:1)Solvent

Conditions

Temperature
40 °C

Procedure

To a solution of the compound 42 in methanol (2 mL), hydrazine monohydrate (98%, 19.5 μL) was added and stirred at 40° C. for overnight. The reaction solution was concentrated and purified by thin-layer chromatography to obtain the title compound (21.4 mg) having the following physical properties.

Workup

  1. concentrationThe reaction solution was concentrated
  2. custompurified by thin-layer chromatography

Sources & evidence

ORD record
ord-a244fffbee60425b828dbfa027369027
Source dataset
uspto-grants-2014_03
Patent number
US08680092B2

Reaction notes

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