Hydrochloric Acid → HCID 86696996, compound

HRID 1191313Notes

Reaction equation

HRID 1191313 reaction equation
[Br:1][C:2]1[C:3]([CH2:10][N:11](C)[C:12](=O)OC(C)(C)C)=[N:4][N:5]([CH3:9])[C:6]=1[C:7]#[N:8].Cl.O1CCOCC1>C(Cl)Cl>[Br:1][C:2]1[C:3]([CH2:10][NH:11][CH3:12])=[N:4][N:5]([CH3:9])[C:6]=1[C:7]#[N:8]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 86696997HCID 86696997, compound

Product 1

HCID 86696996HCID 86696996, compoundYield 117.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a 0° C. solution of compound 47 (1.0 g, 3.0 mmol) in DCM (15 mL) was added 4 N HCl in dioxane (3.8 mL, 15 mmol). Allowed to stir at room temperature for 3 hours, then concentrated under vacuum to give compound 109 (810 mg, quantitative) as a white solid.

Workup

  1. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-397d563c9d8042e2bb5fcbf1ae573461
Source dataset
uspto-grants-2014_03
Patent number
US08680111B2

Reaction notes

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