反应详情

A microwave vial was charged with 1-(3-chloropropyl)-5-methyl-3,4-dihydro-1H-quinolin-2-one (0.081 g, 0.34 mmol), DDQ (0.116 g, 0.51 mmol), dioxane (2 mL) and sealed. After microwave irradiation, 175° C., 10 min, the reaction was diluted with EtOAc (50 mL), washed with sat aqueous NaHCO3 (2×15 mL) and the organic phase was dried (Na2SO4), filtered, concentrated under reduced pressure and the residue was purified with prep RP-HPLC to yield the crude title compound (0.053 g), which was used without further purification. HPLC-MS (ammonium acetate) [M+H]+=236.2.

1. customsealed
2. customAfter microwave irradiation, 175° C., 10 min
3. washwashed
4. dry with materialthe organic phase was dried (Na2SO4)
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure
7. customthe residue was purified with prep RP-HPLC