2-Amino-4-methylthiazole → HCID 60207328, compound

HRID 1192110Notes

Reaction equation

HRID 1192110 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([OH:16])=O)=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[CH3:21][C:22]1[N:23]=[C:24]([NH2:27])[S:25][CH:26]=1>>[Cl:20][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([Cl:1])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([NH:27][C:24]2[S:25][CH:26]=[C:22]([CH3:21])[N:23]=2)=[O:16])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

Participants

3

Reactant 2

HCID 741432-Amino-4-methylthiazoleHCID 602073175-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carboxylic acid

Product 1

HCID 60207328HCID 60207328, compound

Procedure

Prepared according to the procedure described for example 70 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carboxylic acid (200 mg, 0.57 mmol) and 4-methyl-thiazol-2-amine (78 mg, 0.68 mmol). The title compound was obtained as a yellow solid (65 mg, 26% yield). 1H NMR (400 MHz, d6-DMSO) δ: 9.01 (2H, m), 7.24 (1H, m), 6.88 (1H, m), 2.23 (3H, m). MS m/z: 446.92, 448.97 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-59ed8979f07f4e5ab3a03b6af4e94ac5
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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