2,4-Dichloropyrimidine → HCID 43654761, compound

HRID 1192806Notes

Reaction equation

HRID 1192806 reaction equation
Cl[C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[CH:4][N:3]=1.[F:9][C:10]([F:22])([F:21])[O:11][C:12]1[CH:17]=[CH:16][C:15](B(O)O)=[CH:14][CH:13]=1>[Pd]>[Cl:8][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([C:15]2[CH:14]=[CH:13][C:12]([O:11][C:10]([F:9])([F:21])[F:22])=[CH:17][CH:16]=2)[N:7]=1

Participants

4

Reactant 2

HCID 775312,4-DichloropyrimidineHCID 27343864-(Trifluoromethoxy)phenylboronic acid

Product 1

HCID 43654761HCID 43654761, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The title compound was prepared by palladium-catalyzed arylation of 2,4-dichloropyrimidine and 4-trifluoromethoxyphenyl boronic acid: mp 70-73° C.; 1H NMR (400 MHz, CDCl3) δ 8.68 (d, J=5.6 Hz, 1H), 8.16 (d, J=9.1 Hz, 2H), 7.65 (d, J=5.3 Hz, 1H), 7.36 (dd, J=9.2, 0.9 Hz, 2H); EIMS m/z 274 (M+).

Sources & evidence

ORD record
ord-aec2ab62610842338db346ff2a4e766d
Source dataset
uspto-grants-2014_03
Patent number
US08680269B2

Reaction notes

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