反应详情

Potassium carbonate (1.68 g, 12 mmol) was suspended in DMF (50 ml) and isopropylthiol (1 ml, 11 mmol) added. The suspension was stirred at room temperature for 15 minutes before a solution of 5-chloro-1-methyl-3-trifluoromethyl-1H-pyrazole-4-carbaldehyde (2.12 g, 10 mmol) in DMF (5 ml) was added. The reaction was stirred at room temperature for 16 hours. The reaction was partitioned between aqueous ammonium chloride solution and diethyl ether and the two phases were separated. The organic phase was washed with water and brine, dried over sodium sulfate and concentrated to give the product (2.584 g, 100% yield) which was used without further purification. 1H NMR (400 MHz, CDCl3): 1.29 (3H, s, Me), 1.31 (3H, s, Me), 3.52 (1H, heptet, CH), 4.02 (3H, s, Me), 10.03 (1H, s, CH).

1. additionwas added
2. customThe reaction was partitioned between aqueous ammonium chloride solution and diethyl ether
3. customthe two phases were separated
4. washThe organic phase was washed with water and brine
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated