Potassium Phosphate, Tribasic → 2-(4-Benzyloxy-2,6-dimethylphenyl)-3-methoxycyclopent-2-enone

HRID 1193037Notes

Reaction equation

Br[C:2]1[C:3](=[O:9])[CH2:4][CH2:5][C:6]=1[O:7][CH3:8].[CH2:10]([O:17][C:18]1[CH:23]=[C:22]([CH3:24])[C:21](B(O)O)=[C:20]([CH3:28])[CH:19]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.P([O-])([O-])([O-])=O.[K+].[K+].[K+].C1(P(C2CCCCC2)C2C=CC=CC=2C2C(OC)=CC=CC=2OC)CCCCC1>C1(C)C=CC=CC=1.C([O-])(=O)C.[Pd+2].C([O-])(=O)C>[CH2:10]([O:17][C:18]1[CH:23]=[C:22]([CH3:24])[C:21]([C:2]2[C:3](=[O:9])[CH2:4][CH2:5][C:6]=2[O:7][CH3:8])=[C:20]([CH3:28])[CH:19]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

Conditions

Temperature: 90 °C

Procedure

To a suspension of 2-bromo-3-methoxycyclopent-2-enone (5.00 g, 26.0 mmol), 4-benzyloxy-2,6-dimethylphenyl boronic acid (7.20 g, 28 mmol) (described in EP1726580) and potassium phosphate (9.55 g, 45 mmol) in degassed toluene (125 ml) is added palladium (II) acetate (0.135 g, 0.6 mmol) and 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl (0.492 g, 1.2 mmol). The reaction mixture is then heated at 90° C. under a nitrogen atmosphere for 4 hours, then allowed to cool to room temperature. After partitioning between ethyl acetate (500 ml) and distilled water (500 ml), the organic phase is separated and concentrated in vacuo. The crude product is purified by flash column chromatography (ethyl acetate/hexane eluant) to afford 2-(4-benzyloxy-2,6-dimethylphenyl)-3-methoxycyclopent-2-enone as a white solid.

Workup

temperatureto cool to room temperature
customAfter partitioning between ethyl acetate (500 ml)
distillationdistilled water (500 ml)
customthe organic phase is separated
concentrationconcentrated in vacuo
customThe crude product is purified by flash column chromatography (ethyl acetate/hexane eluant)

Sources & evidence

ORD record: ord-c54a6533cc764b0f8fe1de24e9b1e97f
Source dataset: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08680339B2

Reaction notes

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