Trifluoroacetic acid → HCID 86663376, compound

HRID 1193264Notes

Reaction equation

HRID 1193264 reaction equation
[C:1]([OH:7])([C:3]([F:6])([F:5])[F:4])=[O:2].C(OC([NH:15][C@H:16]1[C:24]2[C:19](=[C:20]([F:29])[CH:21]=[C:22]([C:25]([O:27][CH3:28])=[O:26])[CH:23]=2)[CH2:18][CH2:17]1)=O)(C)(C)C>C(Cl)Cl>[F:4][C:3]([F:6])([F:5])[C:1]([OH:7])=[O:2].[NH2:15][C@H:16]1[C:24]2[C:19](=[C:20]([F:29])[CH:21]=[C:22]([C:25]([O:27][CH3:28])=[O:26])[CH:23]=2)[CH2:18][CH2:17]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66799181HCID 66799181, compound

Product 1

HCID 86663376HCID 86663376, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

TFA (4 ml) was added at 0° C. to a solution of (R)-methyl 3-(tert-butoxycarbonylamino)-7-fluoro-2,3-dihydro-1H-indene-5-carboxylate (0.85 g, 2.75 mmol, 1.0 eq.) in DCM (10 ml), and the mixture was stirred for 1 hour at RT. After monitoring by TLC, the reaction mixture was concentrated under reduced pressure, dried and used in the next stage without being purified further. 2) Synthesis of the Acylated & Sulfonylated Amino Acid Esters (B, C & D) General Method for the Synthesis of Amino Acid Esters (B, C & D)

Workup

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. customdried
  3. customwithout being purified further
  4. custom2) Synthesis of the Acylated & Sulfonylated Amino Acid Esters (B, C & D) General Method

Sources & evidence

ORD record
ord-ac1a743f5ca943e991fc33426ab3f1e1
Source dataset
uspto-grants-2014_03
Patent number
US08680159B2

Reaction notes

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