Trifluoroacetic acid → HCID 66799374, compound

HRID 1193322Notes

Reaction equation

HRID 1193322 reaction equation
[CH3:1][O:2][C:3]1[CH:26]=[CH:25][C:6]([CH2:7][N:8]([CH3:24])[CH:9]2[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][C:10]2([CH3:23])[CH3:22])=[CH:5][CH:4]=1.C(O)(C(F)(F)F)=O>ClCCl>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:7][N:8]([CH3:24])[CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][C:10]2([CH3:23])[CH3:22])=[CH:25][CH:26]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66805429HCID 66805429, compound

Product 1

HCID 66799374HCID 66799374, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl 4-((4-methoxybenzyl)(methyl)amino)-3,3-dimethylpiperidine-1-carboxylate (1.87 g, 5.17 mmol, 1 eq) was dissolved in dichloromethane (4 ml); TFA (4 ml) was added at 0° C., and stirring was carried out for 2 h at RT. The reaction solution was concentrated under reduced pressure, taken up in toluene and dried again. The crude product was used in the next stage without being purified further.

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. customdried again
  3. customwithout being purified further

Sources & evidence

ORD record
ord-7754186b3f364da3a006eb60abb2bdc4
Source dataset
uspto-grants-2014_03
Patent number
US08680159B2

Reaction notes

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