Trifluoroacetic acid → HCID 66798634, compound

HRID 1193399Notes

Reaction equation

HRID 1193399 reaction equation
FC(F)(F)C(O)=O.[CH3:8][N:9]([CH:17]1[CH2:22][CH2:21][N:20]([C:23]2[CH:28]=[N:27][CH:26]=[C:25]([CH3:29])[N:24]=2)[CH2:19][CH2:18]1)C(=O)OC(C)(C)C>ClCCl>[CH3:8][NH:9][CH:17]1[CH2:18][CH2:19][N:20]([C:23]2[CH:28]=[N:27][CH:26]=[C:25]([CH3:29])[N:24]=2)[CH2:21][CH2:22]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66799007tert-Butyl methyl(1-(6-methylpyrazin-2-yl)piperidin-4-yl)carbamate

Product 1

HCID 66798634HCID 66798634, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid (2 ml) was added at 0° C. to a solution of tert-butyl methyl(1-(6-methylpyrazin-2-yl)piperidin-4-yl)carbamate (250 mg, 0.816 mmol, 1 eq) in dichloromethane (10 ml) and the reaction mixture was stirred for 2 h at room temperature. Concentration under reduced pressure was then carried out. The crude product so obtained was used in the next stage without being purified further.

Workup

  1. concentrationConcentration under reduced pressure

Sources & evidence

ORD record
ord-0760eee0cf744340aaafa3fb47cf7f95
Source dataset
uspto-grants-2014_03
Patent number
US08680159B2

Reaction notes

Loading…