Triethylamine → HCID 178493597, compound

HRID 1193577Notes

Reaction equation

HRID 1193577 reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[CH3:6][C:7]1([CH3:29])[C:27]2[C:10](=[CH:11][C:12]3[NH:16][C:15]([C:17]4[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][C:18]=4[O:24][CH3:25])=[N:14][C:13]=3[CH:26]=2)[NH:9][C:8]1=[O:28].C(N(CC)CC)C>CN(C)C=O>[CH3:6][C:7]1([CH3:29])[C:27]2[C:10](=[CH:11][C:12]3[NH:16][C:15]([C:17]4[CH:22]=[CH:21][C:20]([O:23][S:2]([CH3:1])(=[O:4])=[O:3])=[CH:19][C:18]=4[O:24][CH3:25])=[N:14][C:13]=3[CH:26]=2)[NH:9][C:8]1=[O:28]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 178493418HCID 178493418, compound

Product 1

HCID 178493597HCID 178493597, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.53 g. (4.6 mmol) methanesulphonyl chloride was added dropwise at 25° C. to a solution of 1.5 g. (4.6 mmol) 7,7-dimethyl-2-(2-methoxy-4-hydroxyphenyl)-6,7-dihydro-3H,5H-pyrrolo[2,3-f]benzimidazol-6-one and 0.46 g. (4.6 mmol) triethylamine in 20 ml. dimethylformamide. After 2 hours, the dimethylformamide was distilled off in a vacuum. The residue was worked up with water and filtered off with suction. The residue was recrystallised from ethanol. There were obtained 1.3 g. (70.6% of theory) of the title compound; m.p. 233°-235° C.

Workup

  1. distillationthe dimethylformamide was distilled off in a vacuum
  2. filtrationfiltered off with suction
  3. customThe residue was recrystallised from ethanol
  4. customThere were obtained 1.3 g

Sources & evidence

ORD record
ord-a949bc3f3c904d9db56b67b3ed9b73fd
Source dataset
uspto-grants-1989_03
Patent number
US04810801

Reaction notes

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