Acetic Acid → HCID 178493620, compound

HRID 1193578Notes

Reaction equation

HRID 1193578 reaction equation
[CH3:1][C:2]1([CH3:25])[C:23]2[C:5](=[CH:6][C:7]3[NH:11][C:10]([C:12]4[CH:17]=[CH:16][C:15]([S:18][CH3:19])=[CH:14][C:13]=4[O:20][CH3:21])=[N:9][C:8]=3[CH:22]=2)[NH:4][C:3]1=[O:24].C(O)(=[O:28])C.OO.[OH2:32]>>[CH3:1][C:2]1([CH3:25])[C:23]2[C:5](=[CH:6][C:7]3[NH:11][C:10]([C:12]4[CH:17]=[CH:16][C:15]([S:18]([CH3:19])(=[O:28])=[O:32])=[CH:14][C:13]=4[O:20][CH3:21])=[N:9][C:8]=3[CH:22]=2)[NH:4][C:3]1=[O:24]

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 784Hydrogen PeroxideHCID 962WaterHCID 178493616HCID 178493616, compound

Product 1

HCID 178493620HCID 178493620, compound

Procedure

200 mg. (0.56 mmol) 7,7-dimethyl-2-(2-methoxy-4-methylthiophenyl)-6,7-dihydro-3H,5H-pyrrolo[2,3-f]-benzimidazol-6-one were stirred for 48 hours at ambient temperature in 4 ml. glacial acetic acid and 0.4 ml. 30% hydrogen peroxide. 10 ml. water were added thereto and the solvent was removed in a vacuum. There were obtained 160 mg. (75% of theory) of the title compound which, after crystallization from ethanol, had a melting point of 235°-237° C.

Workup

  1. customthe solvent was removed in a vacuum
  2. customThere were obtained 160 mg
  3. custom(75% of theory) of the title compound which, after crystallization from ethanol

Sources & evidence

ORD record
ord-bc7cf620eb8d4220b0ed53d0a01b6226
Source dataset
uspto-grants-1989_03
Patent number
US04810801

Reaction notes

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