HCID 53435299, compound → 3,5-Difluoro-4-methoxybenzenepropanoic acid

HRID 1193604Notes

Reaction equation

HRID 1193604 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:11]=[CH:12][C:13]([OH:15])=[O:14])[CH:5]=[C:6]([F:10])[C:7]=1[O:8][CH3:9]>O1CCCC1.[Pd].C(OCC)(=O)C>[F:1][C:2]1[CH:3]=[C:4]([CH2:11][CH2:12][C:13]([OH:15])=[O:14])[CH:5]=[C:6]([F:10])[C:7]=1[O:8][CH3:9]

Participants

5

Reactant 1

HCID 53435299HCID 53435299, compound

Product 1

HCID 140499303,5-Difluoro-4-methoxybenzenepropanoic acid

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Procedure

A solution of 3-(3,5-difluoro-4-methoxyphenyl)propenoic acid (0.078 mol) in tetrahydrofuran (100 ml) and a slurry of 10% palladium on carbon (2 g) in ethyl acetate were reacted substantially as described in Example 7C above to obtain 16.7 g (99%), white crystals: mp 72°-73°.

Workup

  1. customto obtain 16.7 g (99%), white crystals

Sources & evidence

ORD record
ord-fc3286484638461a8f64a9df06303c04
Source dataset
uspto-grants-1989_03
Patent number
US04810811

Reaction notes

Loading…