Sodium ethoxide → 2-ethoxy-1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-4-trifluoromethyl-6(1H)-pyrimidinone

HRID 1193879Notes

Reaction equation

HRID 1193879 reaction equation
Cl[C:2]1[N:3]([C:13]2[CH:18]=[C:17]([O:19][CH:20]([CH3:22])[CH3:21])[C:16]([Cl:23])=[CH:15][C:14]=2[F:24])[C:4](=[O:12])[CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:7]=1.[CH3:25][CH2:26][O-:27].[Na+]>C(O)C>[CH2:26]([O:27][C:2]1[N:3]([C:13]2[CH:18]=[C:17]([O:19][CH:20]([CH3:22])[CH3:21])[C:16]([Cl:23])=[CH:15][C:14]=2[F:24])[C:4](=[O:12])[CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:7]=1)[CH3:25]

Participants

4

Reactant 2

HCID 2723922Sodium ethoxideHCID 212707782-chloro-1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-4-trifluoromethyl-6(1H)-pyrimidinone

Product 1

HCID 212707802-ethoxy-1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-4-trifluoromethyl-6(1H)-pyrimidinone

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

using 2-chloro-1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-4-trifluoromethyl-6(1H)-pyrimidinone and sodium ethylate in ethanol there is obtained 2-ethoxy-1-(4-chloro-2-fluoro -5-isopropoxyphenyl)-4-trifluoromethyl-6(1H)-pyrimidinone, m.p. 101°-103° C.;

Sources & evidence

ORD record
ord-024ead023fc742a2b5584224c95a72eb
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

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