Sodium → HCID 21270754, compound

HRID 1193887Notes

Reaction equation

HRID 1193887 reaction equation
[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:20](=[O:21])[C:19]([F:22])=[C:18]([C:23]([F:26])([F:25])[F:24])[N:17]=[C:16]2Cl)=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5].[Na]>C(O)(C)C>[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:20](=[O:21])[C:19]([F:22])=[C:18]([C:23]([F:26])([F:25])[F:24])[N:17]=[C:16]2[O:6][CH:7]([CH3:9])[CH3:8])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5]

Participants

4

Reactant 2

HCID 5360545SodiumHCID 21270725HCID 21270725, compound

Product 1

HCID 21270754HCID 21270754, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

using isopropyl 2-chloro-5-[2-chloro-5-fluoro-6-oxo-4-trifluoromethyl-1(6H)-pyrimidinyl]-4-fluorobenzoate and sodium isopropylate in isopropanol there is obtained isopropyl 2-chloro-5-[5-fluoro-2-isopropoxy-6-oxo-4-trifluoromethyl-1(6H)-pyrimidinyl]-4-fluorobenzoate, 1H-NMR (CDCl3, 400 MHz): 7.83 ppm (d,1H), 7.40 ppm (d,1H), 5.36 ppm (m,1H), 5.27 ppm (m,1H), 1.39 ppm (d,3H), 1.38 ppm (d,3H), 1.29 ppm (d,3H), 1.28 ppm (d,3H).

Sources & evidence

ORD record
ord-09b3e2fc70374bbc83a92d6bafdfbf2d
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

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