Dimethyl Sulfate → HCID 21270752, compound

HRID 1193889Notes

Reaction equation

HRID 1193889 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:13](=[O:14])[CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[NH:10][C:9]2=[O:19])=[CH:4][C:3]=1[O:20][CH:21]([CH3:23])[CH3:22].S(OC)(O[CH3:28])(=O)=O.C(=O)(O)[O-].[Na+]>CC(C)=O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:13](=[O:14])[CH:12]=[C:11]([C:15]([F:17])([F:18])[F:16])[N:10]=[C:9]2[O:19][CH3:28])=[CH:4][C:3]=1[O:20][CH:21]([CH3:23])[CH3:22]

Participants

5

Reactant 3

HCID 6497Dimethyl SulfateHCID 516892Sodium BicarbonateHCID 21270777HCID 21270777, compound

Product 1

HCID 21270752HCID 21270752, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

using 3-(4-chloro-3-isopropoxyphenyl)-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione with dimethyl sulphate and sodium bicarbonate in acetone there is obtained 1-(4-chloro-3-isopropoxyphenyl)-2-methoxy-4-trifluoromethyl -6(1H)-pyrimidinone. m.p. 55°-58° C.

Sources & evidence

ORD record
ord-c96330bfabd341bab5484eb620e6265d
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

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