Pyridine → HCID 54432997, compound

HRID 1193907Notes

Reaction equation

HRID 1193907 reaction equation
[CH2:1]([O:3][C:4]1[N:5]([C:15]2[CH:20]=[C:19]([OH:21])[C:18]([Cl:22])=[CH:17][C:16]=2[F:23])[C:6](=[O:14])[CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[N:9]=1)[CH3:2].[C:24](Cl)(=[O:28])[CH:25]([CH3:27])[CH3:26].N1C=CC=CC=1>C(OCC)C>[C:24]([O:21][C:19]1[CH:20]=[C:15]([N:5]2[C:6](=[O:14])[CH:7]=[C:8]([C:10]([F:13])([F:11])[F:12])[N:9]=[C:4]2[O:3][CH2:1][CH3:2])[C:16]([F:23])=[CH:17][C:18]=1[Cl:22])(=[O:28])[CH:25]([CH3:27])[CH3:26]

Participants

5

Reactant 3

HCID 1049PyridineHCID 62325Isobutyryl chlorideHCID 21270727HCID 21270727, compound

Product 1

HCID 54432997HCID 54432997, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

using 2-ethoxy-1-(4-chloro-2-fluoro-5-hydroxyphenyl)-4-trifluoromethyl-6(1H)-pyrimidinone and isobutyryl chloride with pyridine in diethyl ether there is obtained {5-[2-ethoxy-6-oxo-4-trifluoromethyl-1(6H)-pyrimidinyl]-2-chloro-4-fluorophenyl} isobutyrate, 1NMR (CDCl3, 400 MHz): 7.38 ppm (d,1H), 7.13 ppm (d,1H), 6.58 ppm (s,1H), 4.50 ppm (m,2H), 2.87 ppm (m,1H), 1.35 ppm (d,3H), 1.34 ppm (d,3H), 1.31 ppm (t,3H);

Sources & evidence

ORD record
ord-99b2f1192e85441488b026e708729872
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

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