Allyl bromide → HCID 21270717, compound

HRID 1193916Notes

Reaction equation

HRID 1193916 reaction equation
[CH2:1]([O:3][C:4]1[N:5]([C:15]2[CH:20]=[C:19]([OH:21])[C:18]([Br:22])=[CH:17][C:16]=2[F:23])[C:6](=[O:14])[CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[N:9]=1)[CH3:2].[CH2:24](Br)[CH:25]=[CH2:26].[H-].[Na+]>CN(C)C=O>[CH2:1]([O:3][C:4]1[N:5]([C:15]2[CH:20]=[C:19]([O:21][CH2:26][CH:25]=[CH2:24])[C:18]([Br:22])=[CH:17][C:16]=2[F:23])[C:6](=[O:14])[CH:7]=[C:8]([C:10]([F:13])([F:11])[F:12])[N:9]=1)[CH3:2]

Participants

5

Reactant 3

HCID 7841Allyl bromideHCID 24758Sodium hydrideHCID 212707472-ethoxy-1-(4-bromo-2-fluoro-5-hydroxyphenyl)-4-trifluoromethyl-6(1H)-pyrimidinone

Product 1

HCID 21270717HCID 21270717, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

using 2-ethoxy-1-(4-bromo-2-fluoro-5-hydroxyphenyl)-4-trifluoromethyl-6(1H)-pyrimidinone and allyl bromide with sodium hydride in dimethylformamide there is obtained 2-ethoxy-1-[4-bromo-2-fluoro-5-(2-propenyloxy)-phenyl]-4-trifluoromethyl-6(1H)-pyrimidinone, m.p. 68°-70° C.;

Sources & evidence

ORD record
ord-6785f2092f3147acb9dec7abd3e03e60
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

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