Phosphorus oxychloride → HCID 21270698, compound

HRID 1193936Notes

Reaction equation

HRID 1193936 reaction equation
[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:20](=[O:21])[CH:19]=[C:18]([C:22]([F:28])([F:27])[C:23]([F:26])([F:25])[F:24])[NH:17][C:16]2=O)=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5].P(Cl)(Cl)([Cl:32])=O>N1C=CC=CC=1>[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:20](=[O:21])[CH:19]=[C:18]([C:22]([F:27])([F:28])[C:23]([F:26])([F:25])[F:24])[N:17]=[C:16]2[Cl:32])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:8])[CH3:9])=[O:5]

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 21270707HCID 21270707, compound

Product 1

HCID 21270698HCID 21270698, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

using isopropyl 2-chloro-5-[3,6-dihydro-2,6-dioxo-4-pentafluoroethyl-1(2H)-pyrimidinyl]-4-fluorobenzoate with phosphorus oxychloride and pyridine within 1 hour at room temperature there is obtained isopropyl 2-chloro-5-[2-chloro-6-oxo-4-pentafluoroethyl-1(6H)-pyrimidinyl]4-fluorobenzoate, 1H-NMR (CDCl3, 60 MHz): 7.90 ppm (d,1H), 7.48 ppm (d,1H), 6.96 ppm (s,1H), 5.30 ppm (m,1H), 1.40 ppm (d,6H);

Workup

  1. customwithin 1 hour
  2. customat room temperature

Sources & evidence

ORD record
ord-0f8b2667aa224f69b28370dca2e08b93
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

Loading…