Carbon Dioxide → HCID 21271307, compound

HRID 1194046Notes

Reaction equation

HRID 1194046 reaction equation
C(=O)=O.[P:4]([Cl:7])(Cl)Cl.[C:8]([NH:12][CH2:13][CH:14]([OH:29])[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])([CH3:11])([CH3:10])[CH3:9].C(N(CC)CC)C>ClCCl.CC(C)=O>[C:8]([N:12]1[CH2:13][CH:14]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[O:29][P:4]1[Cl:7])([CH3:10])([CH3:11])[CH3:9]

Participants

7

Reactant 4

HCID 280Carbon DioxideHCID 8471TriethylamineHCID 24387Phosphorus trichlorideHCID 21271308HCID 21271308, compound

Product 1

HCID 21271307HCID 21271307, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 6344DichloromethaneSolvent2×

Procedure

To a CO2 (s)/acetone cooled solution of 10.5 ml (0.077 mol) of phosphorus trichloride in 150 ml of dichloromethane is added dropwise a solution of 24.0 g (0.077 mol) of 1-tert-butylamino-2-hexadecanol and 21.3 mol (0.153 mol) of triethylamine in 37.5 ml of dichloromethane over a five minute period. When the addition is completed, the cooling bath is replaced with a 50° C. water bath for 1 hour. This is then stirred at room temperature for 16 hours.

Workup

  1. additionWhen the addition
  2. customis replaced with a 50° C.
  3. customfor 1 hour

Sources & evidence

ORD record
ord-e245511d646248a4a0ddff3909b43c46
Source dataset
uspto-grants-1989_03
Patent number
US04812501

Reaction notes

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