Anisole → HCID 178503584, compound

HRID 1194289Notes

Reaction equation

HRID 1194289 reaction equation
[CH3:1][S:2][C:3]1[N:4]=[C:5]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=[C:6]2[N:7]=1.[C:13]1(OC)C=CC=CC=1.[F:21][C:22]([F:29])([F:28])[S:23]([O:26]C)(=[O:25])=[O:24]>C(OCC)(=O)C>[F:21][C:22]([F:29])([F:28])[S:23]([O-:26])(=[O:25])=[O:24].[CH3:13][N:7]1[C:6]2=[CH:8][CH:9]=[CH:10][CH:11]=[CH:12][C:5]2=[NH+:4][CH:3]1[S:2][CH3:1]

Participants

5

Reactant 3

HCID 7519AnisoleHCID 9526Methyl triflateHCID 151230382-Methylthiocycloheptimidazole

Product 1

HCID 178503584HCID 178503584, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

First, 25 g of 2-methylthiocycloheptimidazole was added to 100 ml of anisole, and stirred under ice cooling. Then, 28 g of methyl trifluoromethanesulfonate was added dropwise and stirred under ice cooling. The mixture was further stirred at room temperature for 2 hours and 30 minutes, 200 ml of ethyl acetate was added thereto, and deposited crystals were filtered and dried.

Workup

  1. stirringstirred under ice cooling
  2. stirringThe mixture was further stirred at room temperature for 2 hours and 30 minutes
  3. filtrationwere filtered
  4. customdried

Sources & evidence

ORD record
ord-ae87d2e397e94c91a2716070b4f1ac09
Source dataset
uspto-grants-1989_03
Patent number
US04814265

Reaction notes

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