5-Bromo-2,4-dichloropyrimidine → HCID 14256954, compound

HRID 1194308Notes

Reaction equation

HRID 1194308 reaction equation
[Br:1][C:2]1[C:3](Cl)=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1.[S-:10][C:11]#[N:12].[K+]>>[Br:1][C:2]1[C:3]([S:10][C:11]#[N:12])=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 2899735-Bromo-2,4-dichloropyrimidineHCID 516872Potassium thiocyanate

Product 1

HCID 14256954HCID 14256954, compoundYield 80%

Procedure

In 100 ml of formid acid, a reaction of 23.0 g of 5-bromo-2,4-dichloropyrimidine and 10.0 g of potassium thiocyanate was conducted at room temperature (20° C.) for 4 hours in a similar manner as Synthesis Example 1. Then, the reaction mixture was treated in a similar procedure as Synthesis Example 1, there was obtained a 80.0% yield of 5-bromo-2-chloro-4-thiocyanopyrimidine, m.p. 166.5°-170° C.

Workup

  1. customwas conducted at room temperature
  2. custom(20° C.)
  3. customfor 4 hours
  4. customas Synthesis Example 1
  5. additionThen, the reaction mixture was treated in a similar procedure as Synthesis Example 1

Sources & evidence

ORD record
ord-cbf7b7cca2014e61bf3771c4e212f07d
Source dataset
uspto-grants-1989_03
Patent number
US04814337

Reaction notes

Loading…