Hydrochloric Acid → HCID 54724109, compound

HRID 1194393Notes

Reaction equation

HRID 1194393 reaction equation
[ClH:1].[CH2:2]([N:4]([CH2:7][CH2:8][CH2:9][NH:10][C:11]([C:13]1[N:14]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:15]2[C:20]([C:21]=1[O:22]C)=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:12])[CH2:5][CH3:6])[CH3:3].Cl>CO>[ClH:1].[CH2:2]([N:4]([CH2:7][CH2:8][CH2:9][NH:10][C:11]([C:13]1[N:14]([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)[C:15]2[C:20]([C:21]=1[OH:22])=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:12])[CH2:5][CH3:6])[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 13136011HCID 13136011, compound

Product 1

HCID 54724109HCID 54724109, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2.1 g of 2-[3-(N,N-diethylamino)propylaminocarbonyl]-3-methoxy-1-phenylindole hydrochloride are dissolved in 5 ml of methanol and mixed with 2.5 ml concentrated hydrochloric acid. The reaction mixture is boiled for 3 h under reflux and subsequently evaporated under vacuum. 1.66 g (82% of theoretical) 2-[3-(N,N-diethylamino)propylaminocarbonyl]-3-hydroxy-1-phenylindole hydrochloride are obtained as an oily substance. IR: 1647 cm-1 (CO amide).

Workup

  1. temperatureunder reflux
  2. customsubsequently evaporated under vacuum

Sources & evidence

ORD record
ord-56f683bd7dac4d0598c74444208735b8
Source dataset
uspto-grants-1989_03
Patent number
US04814345

Reaction notes

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