Cyanoacetamide → HCID 13772058, compound

HRID 1194495Notes

Reaction equation

HRID 1194495 reaction equation
[C:1]([C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7](=O)[NH:6][CH:5]=1)(=O)[CH3:2].[C:15](C1C=C(C2CCCCC2=O)C=CN=1)(=O)[CH3:16].[C:31]([CH2:33][C:34]([NH2:36])=[O:35])#[N:32]>>[C:31]([C:33]1[C:34](=[O:35])[NH:36][C:15]([CH3:16])=[C:1]2[C:4]=1[CH2:5][CH2:6][CH:7]([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][N:13]=1)[CH2:2]2)#[N:32]

Participants

4

Reactant 3

HCID 7898CyanoacetamideHCID 131201644-Acetylisoquinolin-1(2H)-oneHCID 53904154HCID 53904154, compound

Product 1

HCID 13772058HCID 13772058, compound

Procedure

Conventionally, these 4-acetyl isoquinolinone compounds have been prepared by condensing 2-acetyl-4-pyridyl cyclohexanone with cyanoacetamide to produce 4-cyano-1-methyl-7-pyridyl-5,6,7,8-tetrahydro-3(2H)-isoquinolinone and then reacting the obtained compound with a Grignard reagent such as methyl magnesium iodide and the like followed by decomposition by an acid.

Sources & evidence

ORD record
ord-3226e4351414445cac0439f8100cc877
Source dataset
uspto-grants-1989_03
Patent number
US04814458

Reaction notes

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